Last update
9/19/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Good
Based on 95 Reviews
8.2
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Iron (elemental) (from 180 mg Ferrous Bisglycinate)(Ferrochel™)
36 mg
200%
Top Medical Research Studies
8
We examined how curcumin-mediated photodynamic therapy (CUR-PDT) induces a specific type of cell death called ferroptosis in fibroblast-like synoviocytes from rheumatoid arthritis patients.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Read More
7
We explored the impact of iron accumulation in multiple sclerosis (MS) lesions using advanced MRI techniques. Tracking 50 participants over an average of 3.3 years, we observed that iron deposits, identified as hyper-paramagnetic signals (HPS), closely linked with impaired remyelination and greater disability. Specifically, lesions with early signs of HPS showed a significant decline in myelin recovery compared to those without such deposits. These findings suggest that measuring iron levels could guide therapies aimed at enhancing myelin repair in MS patients.
Read More
8
Ferroportin regulates RA cell activity
We aimed to understand how iron affects autoimmune disorders, specifically focusing on rheumatoid arthritis (RA). Our study explored the function of ferroportin (FPN), a membrane iron transporter, in the proliferation and movement of fibroblast-like synoviocytes (FLS) linked to RA.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
Read More
Most Useful Reviews
9
Raised hemoglobin levels
618 people found this helpful
This is the best iron for treating my autoimmune disorder during pregnancy. Despite various prescriptions failing to help, I turned to this product. Within three weeks, my haemoglobin rose from 96 to 123, and ferritin increased from 40 to nearly 90. I also experienced no gastrointestinal issues, unlike previous products. I'm glad to share my experience; it really works!
Read More
9
Improved energy levels
391 people found this helpful
This supplement worked wonders for my friend with an autoimmune disorder causing severe anaemia. After struggling with other iron supplements, she started this one. Her haemoglobin rose from 117 to 143 without any side effects, helping her feel much better and return to work. Seeing her results inspired me to order for myself to prevent low iron levels.
Read More
9
Effective anaemia treatment
277 people found this helpful
This supplement has become my go-to remedy for anaemia related to my autoimmune disorder. I take it in cycles and have almost forgotten my previous struggles with low iron levels. It effectively addresses my deficiencies and I plan to continue ordering this wonderful product.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
- All Researches
8
Ferroportin regulates RA cell activity
We aimed to understand how iron affects autoimmune disorders, specifically focusing on rheumatoid arthritis (RA). Our study explored the function of ferroportin (FPN), a membrane iron transporter, in the proliferation and movement of fibroblast-like synoviocytes (FLS) linked to RA.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
Read More
8
We examined how curcumin-mediated photodynamic therapy (CUR-PDT) induces a specific type of cell death called ferroptosis in fibroblast-like synoviocytes from rheumatoid arthritis patients.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Read More
7
We explored the impact of iron accumulation in multiple sclerosis (MS) lesions using advanced MRI techniques. Tracking 50 participants over an average of 3.3 years, we observed that iron deposits, identified as hyper-paramagnetic signals (HPS), closely linked with impaired remyelination and greater disability. Specifically, lesions with early signs of HPS showed a significant decline in myelin recovery compared to those without such deposits. These findings suggest that measuring iron levels could guide therapies aimed at enhancing myelin repair in MS patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 95 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Raised hemoglobin levels
618 people found this helpful
This is the best iron for treating my autoimmune disorder during pregnancy. Despite various prescriptions failing to help, I turned to this product. Within three weeks, my haemoglobin rose from 96 to 123, and ferritin increased from 40 to nearly 90. I also experienced no gastrointestinal issues, unlike previous products. I'm glad to share my experience; it really works!
Read More
9
Improved energy levels
391 people found this helpful
This supplement worked wonders for my friend with an autoimmune disorder causing severe anaemia. After struggling with other iron supplements, she started this one. Her haemoglobin rose from 117 to 143 without any side effects, helping her feel much better and return to work. Seeing her results inspired me to order for myself to prevent low iron levels.
Read More
9
Effective anaemia treatment
277 people found this helpful
This supplement has become my go-to remedy for anaemia related to my autoimmune disorder. I take it in cycles and have almost forgotten my previous struggles with low iron levels. It effectively addresses my deficiencies and I plan to continue ordering this wonderful product.
Read More
7.5
Increased ferritin levels
1272 people found this helpful
Effective iron! After my ferritin level dropped to 18.3, I experienced extreme fatigue. I opted for this easily digestible iron bisglycinate after considering many options. I took 1 tablet twice daily, increasing to 2 during menstruation, alongside buffered vitamin C. Within a month, my ferritin significantly improved. The price and quality were excellent, and I advise anyone struggling with low ferritin to try it.
Read More
9
Normalised iron levels
49 people found this helpful
I suffer from iron deficiency anaemia. I tried many treatments with limited success until finding this medication, which has a therapeutic dosage of 36 mg. After adjusting my intake, my analysis revealed a significant improvement in my serum iron and haemoglobin levels.
Read More
Frequently Asked Questions
9
Raised hemoglobin levels
618 people found this helpful
This is the best iron for treating my autoimmune disorder during pregnancy. Despite various prescriptions failing to help, I turned to this product. Within three weeks, my haemoglobin rose from 96 to 123, and ferritin increased from 40 to nearly 90. I also experienced no gastrointestinal issues, unlike previous products. I'm glad to share my experience; it really works!
7.5
Increased energy
5 people found this helpful
I ordered this product to increase my low haemoglobin levels due to my autoimmune disorder. By the second week, I noticed greater endurance and reduced weakness, along with increased energy. I have limited my intake of caffeine-containing products and take two tablets in the morning with a vitamin. It's advisable to have a ferritin and haemoglobin test before starting the supplement.
9
Improved symptoms
4 people found this helpful
My symptoms of anaemia have improved dramatically. After 13 days of use, I observed a significant reduction in dizziness and light-headedness, with noticeable pink colour returning to my cheeks. Although I began using protein and niacin at the same time, this supplement seems to elevate my ferritin level. I took one tablet post-dinner with vitamin C for better iron absorption. Despite some side effects at higher doses, my mood has improved, leading me to gradually increase my intake to three tablets a day.
10
Returned to normal
23 people found this helpful
Due to iron deficiency (ferritin 4.9), I developed a panic disorder and was prescribed ineffective medicines. After a year and a half of taking three tablets daily, my ferritin reached 200. Now, I'm reducing it to one tablet, feeling much better.
10
Cured anaemia
1 people found this helpful
A quick remedy for anaemia! After my doctor indicated low haemoglobin, I ordered this product. I noticed a dramatic improvement within a week, and now my complexion looks vibrant!
9
Well absorbed
5 people found this helpful
With low ferritin and menstrual related iron loss, I purchased this on my nutritionist's recommendation. The dosage is effective when taken with vitamin C. I experienced no gastrointestinal issues, and the supplement was well absorbed.
7.5
Increased ferritin levels
1272 people found this helpful
Effective iron! After my ferritin level dropped to 18.3, I experienced extreme fatigue. I opted for this easily digestible iron bisglycinate after considering many options. I took 1 tablet twice daily, increasing to 2 during menstruation, alongside buffered vitamin C. Within a month, my ferritin significantly improved. The price and quality were excellent, and I advise anyone struggling with low ferritin to try it.
9
Improved haemoglobin
2 people found this helpful
This is the only iron supplement that has worked for me. I took it on an empty stomach, combined with lysine, proline, and glycine, without any gastrointestinal issues. Over two months, my haemoglobin increased from 87 to 139 and ferritin from 4 to 26.
9
Significant improvement
20 people found this helpful
I found myself anaemic last winter, confirmed by tests. After conceiving a comprehensive approach with B12, I took iron. A month later, my levels increased significantly. I noticed improved health and energy without any side effects. Highly recommended!
9
Normalised iron levels
49 people found this helpful
I suffer from iron deficiency anaemia. I tried many treatments with limited success until finding this medication, which has a therapeutic dosage of 36 mg. After adjusting my intake, my analysis revealed a significant improvement in my serum iron and haemoglobin levels.
8
Ferroportin regulates RA cell activity
We aimed to understand how iron affects autoimmune disorders, specifically focusing on rheumatoid arthritis (RA). Our study explored the function of ferroportin (FPN), a membrane iron transporter, in the proliferation and movement of fibroblast-like synoviocytes (FLS) linked to RA.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
8
We examined how curcumin-mediated photodynamic therapy (CUR-PDT) induces a specific type of cell death called ferroptosis in fibroblast-like synoviocytes from rheumatoid arthritis patients.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
7
We explored the impact of iron accumulation in multiple sclerosis (MS) lesions using advanced MRI techniques. Tracking 50 participants over an average of 3.3 years, we observed that iron deposits, identified as hyper-paramagnetic signals (HPS), closely linked with impaired remyelination and greater disability. Specifically, lesions with early signs of HPS showed a significant decline in myelin recovery compared to those without such deposits. These findings suggest that measuring iron levels could guide therapies aimed at enhancing myelin repair in MS patients.
References
- Shao W, Liu F, Zhu L, Qian W, Meng Q, et al. Ferroportin inhibits the proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis via regulating ROS/PI3K/AKT signaling pathway. Eur J Pharmacol. 2025;987:177205. 10.1016/j.ejphar.2024.177205
- Sun L, Niu Y, Liao B, Liu L, Peng Y, et al. CUR-PDT induces ferroptosis of RA-FLS via the Nrf2/xCT/GPX4 pathway to inhibit proliferation in rheumatoid arthritis. Inflamm Res. 2025;74:53. 10.1007/s00011-025-02019-2
- Shin HG, Kim W, Lee JH, Lee HS, Nam Y, et al. Association of iron deposition in MS lesion with remyelination capacity using susceptibility source separation MRI. Neuroimage Clin. 2025;45:103748. 10.1016/j.nicl.2025.103748
