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SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Excellent
Based on 95 Reviews
9
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Iron (elemental) (from 180 mg Ferrous Bisglycinate)(Ferrochelâ„¢)
36 mg
200%
Top Medical Research Studies
8
Ferroportin regulates RA cell activity
Ferroportin inhibits the proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis via regulating ROS/PI3K/AKT signaling pathway.
Study highlights iron's RA role
We aimed to understand how iron affects autoimmune disorders, specifically focusing on rheumatoid arthritis (RA). Our study explored the function of ferroportin (FPN), a membrane iron transporter, in the proliferation and movement of fibroblast-like synoviocytes (FLS) linked to RA.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
Read More
Most Useful Reviews
9.5
Raised hemoglobin levels
This is the best iron for treating my autoimmune disorder during pregnancy. Despite various prescriptions failing to help, I turned to this product. Within three weeks, my haemoglobin rose from 96 to 123, and ferritin increased from 40 to nearly 90. I also experienced no gastrointestinal issues, unlike previous products. I'm glad to share my experience; it really works!
Read More
9.5
Improved energy levels
This supplement worked wonders for my friend with an autoimmune disorder causing severe anaemia. After struggling with other iron supplements, she started this one. Her haemoglobin rose from 117 to 143 without any side effects, helping her feel much better and return to work. Seeing her results inspired me to order for myself to prevent low iron levels.
Read More
9.5
Effective anaemia treatment
This supplement has become my go-to remedy for anaemia related to my autoimmune disorder. I take it in cycles and have almost forgotten my previous struggles with low iron levels. It effectively addresses my deficiencies and I plan to continue ordering this wonderful product.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
8
Ferroportin regulates RA cell activity
Ferroportin inhibits the proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis via regulating ROS/PI3K/AKT signaling pathway.
Study highlights iron's RA role
We aimed to understand how iron affects autoimmune disorders, specifically focusing on rheumatoid arthritis (RA). Our study explored the function of ferroportin (FPN), a membrane iron transporter, in the proliferation and movement of fibroblast-like synoviocytes (FLS) linked to RA.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
Read More
User Reviews
USERS' SCORE
Excellent
Based on 95 Reviews
9
10
Returned to normal
Due to iron deficiency (ferritin 4.9), I developed a panic disorder and was prescribed ineffective medicines. After a year and a half of taking three tablets daily, my ferritin reached 200. Now, I'm reducing it to one tablet, feeling much better.
10
Cured anaemia
A quick remedy for anaemia! After my doctor indicated low haemoglobin, I ordered this product. I noticed a dramatic improvement within a week, and now my complexion looks vibrant!
9.5
Raised hemoglobin levels
This is the best iron for treating my autoimmune disorder during pregnancy. Despite various prescriptions failing to help, I turned to this product. Within three weeks, my haemoglobin rose from 96 to 123, and ferritin increased from 40 to nearly 90. I also experienced no gastrointestinal issues, unlike previous products. I'm glad to share my experience; it really works!
Read More
9.5
Improved energy levels
This supplement worked wonders for my friend with an autoimmune disorder causing severe anaemia. After struggling with other iron supplements, she started this one. Her haemoglobin rose from 117 to 143 without any side effects, helping her feel much better and return to work. Seeing her results inspired me to order for myself to prevent low iron levels.
Read More
9.5
Effective anaemia treatment
This supplement has become my go-to remedy for anaemia related to my autoimmune disorder. I take it in cycles and have almost forgotten my previous struggles with low iron levels. It effectively addresses my deficiencies and I plan to continue ordering this wonderful product.
